2. GPCR/G Protein
  3. PACAP Receptor
  4. PA-9

PA-9 是一种垂体腺苷酸环化酶激活多肽 (PACAP) I 型 (PAC1) 受体拮抗剂。PA-9 剂量依赖性地抑制 PACAP 诱导的 cAMP 升高，IC50 为 5.6 nM。PA-9 可用于研究神经性和/或炎症性疼痛。

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PA-9 Chemical Structure

PA-9 Chemical Structure

CAS No. : 1436004-46-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥6380
In-stock
1 mg ￥2000
In-stock
5 mg ￥5800
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

PA-9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC50 of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain[1].

IC50 & Target[1]

PAC1 receptor

 

体外研究
(In Vitro)

PA-9 (10 pM to 10 nM; 30 minutes) dose dependently inhibits PACAP-induced (1 nM) CREB phosphorylation in the CHO cells expressing PAC1 receptors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PA-9 相关抗体:
体内研究
(In Vivo)

PA-9 (100 pmol; co-injection with PACAP) attenuates the development of PACAP-induced (100 pmol/5 μL; intrathecal injection) aversive responses of mice[1].
PA-9 (100 pmol; co-injection with PACAP) significantly blocks the induction of PACAP-induced (100 pmol) mechanical allodynia[1].
PA-9 (100 pmol/5 μl; single intrathecal injection alone) does not induce aversive responses and mechanical allodynia of mice[1].
PA-9 is well accommodated in the subpocket formed by L80, F81, I83, G91, V92, P107, A112, and C113 of the PAC1 receptor, precipitating in hydrophobic interactions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (6 weeks old at the start of experiments; intrathecal injection 100 pmol/5 μL PACAP)[1]
Dosage: intrathecal injection, co-injection with PACAP.
Administration: 100 pmol/5 μL
Result: Attenuated the development of PACAP-induced aversive responses.
Blocked the induction of PACAP-induced mechanical allodynia.
分子量

338.36

Formula

C17H18N6O2
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (738.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9554 mL 14.7772 mL 29.5543 mL
5 mM 0.5911 mL 2.9554 mL 5.9109 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

PA-9 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9554 mL 14.7772 mL 29.5543 mL 73.8858 mL
5 mM 0.5911 mL 2.9554 mL 5.9109 mL 14.7772 mL
10 mM 0.2955 mL 1.4777 mL 2.9554 mL 7.3886 mL
15 mM 0.1970 mL 0.9851 mL 1.9703 mL 4.9257 mL
20 mM 0.1478 mL 0.7389 mL 1.4777 mL 3.6943 mL
25 mM 0.1182 mL 0.5911 mL 1.1822 mL 2.9554 mL
30 mM 0.0985 mL 0.4926 mL 0.9851 mL 2.4629 mL
40 mM 0.0739 mL 0.3694 mL 0.7389 mL 1.8471 mL
50 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4777 mL
60 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2314 mL
80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9236 mL
100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7389 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA-91436004-46-4PA9PA 9PACAP ReceptorPituitary adenylyl cyclase activating polypeptide receptormiceinflammatory painneuropathic painCHO cellsPACAPInhibitorinhibitorinhibit

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目录号：
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